Description

Pentamethylbenzenesulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative, valued for its role as a versatile sulfonylation and protecting group reagent in advanced organic synthesis. Its sterically hindered pentamethylbenzene structure offers unique selectivity and reactivity profiles, making it a critical intermediate for constructing complex molecules. This high-purity compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific sulfonyl group chemistry.
• Peptide Chemistry: Serves as a protecting group reagent for amines during solid-phase and solution-phase peptide synthesis.
• Material Science: Intermediate for creating specialized polymers, dyes, and photoacid generators (PAGs) used in advanced lithography.
• Chemical Research: A valuable tool in academic and industrial R&D for exploring new reaction pathways and creating novel chemical entities.
• Cross-Coupling Reactions: Can be utilized in metal-catalyzed coupling reactions to introduce the pentamethylbenzenesulfonyl moiety into target structures.

Basic Information

Product Name	Pentamethylbenzenesulfonyl Chloride
CAS No.	52499-94-2
Molecular Formula	C11H15ClO2S
Molecular Weight	246.75 g/mol
Synonyms	1,2,3,4,5-Pentamethylbenzenesulfonyl Chloride; Pentamethylphenylsulfonyl Chloride; PMS-Cl; 2,3,4,5,6-Pentamethylbenzenesulfonyl Chloride; Pentamethylbenzene-1-sulfonyl Chloride; 1-(Chlorosulfonyl)-2,3,4,5,6-pentamethylbenzene; Pentamethylbenzenesulphonyl Chloride
EINECS	Contact for details

Quality Control

Our Pentamethylbenzenesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.