Description

4-(2,2,5,5-Tetramethylpyrrolidine-1-Oxyl)-4-Fluorosulfonylbenzamide is a specialized nitroxide radical precursor and a key intermediate in organic synthesis. This compound matters for its unique bifunctional structure, combining a stable TEMPO-type radical moiety with a reactive fluorosulfonyl group, enabling advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and polymer industries for applications such as spin labeling, controlled radical polymerization, and the synthesis of novel sulfonamide-based active compounds.

Application

• Spin Labeling Agent: Used in Electron Paramagnetic Resonance (EPR) spectroscopy and imaging to study molecular dynamics and structure in biological systems and materials science.
• Polymer Chemistry Intermediate: Serves as a functional initiator or mediator in Nitroxide-Mediated Radical Polymerization (NMRP) for creating well-defined, complex polymer architectures.
• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly those containing sulfonamide pharmacophores with potential radical scavenging properties.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients for crop protection agents.
• Material Science Research: Used in the development of advanced functional materials, including organic magnets and conductive polymers.
• Bioconjugation: The fluorosulfonyl group allows for selective reactions with amines, enabling the labeling of proteins, peptides, and other biomolecules.

Basic Information

Product Name	4-(2,2,5,5-Tetramethylpyrrolidine-1-Oxyl)-4-Fluorosulfonylbenzamide
CAS No.	52413-15-7
Molecular Formula	C15H20FN2O4S
Molecular Weight	343.39 g/mol
Synonyms	4-Fluorosulfonyl-2,2,5,5-tetramethyl-3-pyrrolin-1-oxylbenzamide; 4-(TEMPO)-4-fluorosulfonylbenzamide; 4-(2,2,5,5-Tetramethyl-1-oxypyrrolidin-3-yl)fluorosulfonylbenzamide; 4-(1-Oxyl-2,2,5,5-tetramethylpyrrolidin-3-yl)fluorosulfonylbenzamide; 4-Fluorosulfonyl-TEMPO-benzamide; Benzamide, 4-(2,2,5,5-tetramethyl-1-oxido-3-pyrrolinyl)sulfonyl fluoride; 4-(2,2,5,5-Tetramethyl-δ³-pyrrolin-1-oxyl)fluorosulfonylbenzamide
EINECS	Contact for details

Quality Control

Our production of 4-(2,2,5,5-Tetramethylpyrrolidine-1-Oxyl)-4-Fluorosulfonylbenzamide adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.