Description

Hydroxypepstatin CAS NO 52329-53-0 is a potent and specific inhibitor of aspartic proteases, including pepsin and renin. This compound is a critical research tool for studying enzyme mechanisms and for the development of therapeutic agents targeting proteolytic pathways. It is essential for pharmaceutical R&D, academic biochemistry research, and the development of diagnostic assays.

Application

• Biochemical Research: Used as a specific inhibitor to study the structure, function, and inhibition kinetics of aspartic proteases like pepsin, cathepsin D, and renin.
• Pharmaceutical Development: Serves as a lead compound or reference standard in drug discovery programs targeting hypertension (via renin inhibition) and other diseases involving aspartic proteases.
• Enzyme Characterization: Employed in enzymatic assays to determine the contribution of aspartic proteases in complex biological samples or reaction mixtures.
• Diagnostic Reagent Manufacturing: Used in the formulation of specialized diagnostic kits that require controlled inhibition of specific protease activities.
• Academic & Industrial R&D: A fundamental reagent in laboratories focused on proteolysis, protein chemistry, and medicinal chemistry.

Basic Information

Product Name	Hydroxypepstatin
CAS No.	52329-53-0
Molecular Formula	C34H63N3O9
Molecular Weight	657.89 g/mol
Synonyms	Hydroxy-Pepstatin; Hydroxypepstatin A; (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoic Acid-(2R,3R,4S,5S)-3-hydroxy-2-[(2S)-2-[(2S,3S)-3-hydroxy-2-[(2R)-2-hydroxy-4-methylpentanamido]butanamido]-3-methylpentanamido]-5-methylheptanoic Acid Derivative; Pepstatin Derivative; Aspartic Protease Inhibitor
EINECS	Contact for details

Quality Control

Our Hydroxypepstatin is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is analyzed using advanced techniques including HPLC and NMR to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.