Description

Asc-J9 is a potent and selective small-molecule inhibitor of the androgen receptor (AR), widely recognized in biochemical and pharmaceutical research. Its primary value lies in its ability to induce AR degradation, offering a distinct mechanism of action compared to traditional antagonists, which makes it a critical tool for studying hormone-dependent pathways. This compound is essential for researchers and developers in the fields of oncology, endocrinology, and drug discovery, particularly for investigating prostate cancer and other androgen-related disorders. Asc-J9 CAS NO 52328-98-0 represents a high-purity research chemical for advancing therapeutic innovation.

Application

• Biomedical Research: A key pharmacological tool for studying androgen receptor signaling, degradation mechanisms, and transcriptional activity in cell-based assays.
• Oncology R&D: Investigation of novel therapeutic strategies for androgen-dependent cancers, such as prostate cancer, by targeting AR protein stability.
• Drug Discovery: Serving as a reference compound or lead molecule in the development of new-generation anti-androgen therapies.
• Endocrine Disorder Studies: Research into conditions like androgenetic alopecia, benign prostatic hyperplasia (BPH), and other hormone-mediated pathologies.
• Mechanistic Biology: Elucidation of protein degradation pathways, including ubiquitin-proteasome system interactions, using AR as a model protein.
• Preclinical Evaluation: Utilization in animal model studies to assess the efficacy and pharmacokinetics of AR-targeting interventions.

Basic Information

Product Name	Asc-J9
CAS No.	52328-98-0
Molecular Formula	C₂₀H₁₈N₂O₃
Molecular Weight	334.37 g/mol
Synonyms	ASC-J9; 1-(4-ethylphenyl)-2-methyl-3-(4-nitrophenyl)-1H-pyrrole-5-carboxamide; Androgen Receptor Degrader ASC-J9; AR Degrader ASC-J9; CAS 52328-98-0; Pyrrole-5-carboxamide, 1-(4-ethylphenyl)-2-methyl-3-(4-nitrophenyl)-1H-; (S)-ASC-J9 (enantiomer)
EINECS	Contact for details

Quality Control

Our Asc-J9 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA), documenting identity, purity, and impurity profiles, is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.