Description

5-Acetamidonaphthalene-1-Sulfonyl Chloride is a specialized organic intermediate featuring a reactive sulfonyl chloride group and a protected amine. This compound is highly valued for its role as a key building block in the synthesis of complex molecules, particularly fluorescent dyes and labeling reagents. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for coupling reactions and derivatization.

Application

• Fluorescent Probe Synthesis: A critical precursor for developing naphthalene-based fluorescent tags and sensors used in bioimaging and diagnostic assays.
• Pharmaceutical Intermediates: Serves as a versatile building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring sulfonamide linkages.
• Agrochemical Development: Used in the research and production of advanced crop protection agents and herbicides.
• Polymer & Material Science: Employed as a monomer or cross-linking agent for creating specialty polymers with specific optical or chemical properties.
• Bioconjugation Reagents: Utilized for labeling proteins, peptides, and other biomolecules due to the reactivity of the sulfonyl chloride group with amines.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for constructing complex naphthalene derivatives and exploring new chemical reactions.

Basic Information

Product Name	5-Acetamidonaphthalene-1-Sulfonyl Chloride
CAS No.	52218-37-8
Molecular Formula	C₁₂H₁₀ClNO₃S
Molecular Weight	283.73 g/mol
Synonyms	1-(5-Acetamidonaphthalen-1-yl)sulfonyl chloride; 5-Acetamido-1-naphthalenesulfonyl chloride; N-[5-(Chlorosulfonyl)naphthalen-1-yl]acetamide; 1-Naphthalenesulfonyl chloride, 5-acetamido-; 5-Acetamido-1-naphthalenesulphonyl chloride; 5-Acetamidonaphthalene-1-sulfochloride; 5-Acetamido-1-naphthylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Acetamidonaphthalene-1-Sulfonyl Chloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.