Description

2-(Trifluoromethyl)Benzenesulfonyl Fluoride is a high-purity, reactive organofluorine building block essential for advanced chemical synthesis. Its unique trifluoromethyl and sulfonyl fluoride functional groups make it a critical intermediate for introducing fluorinated motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, protease inhibitors, and other bioactive molecules containing a trifluoromethylphenyl moiety.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, coatings, and resins with unique surface properties.
• Chemical Biology & Proteomics: Acts as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors due to the electrophilic sulfonyl fluoride group.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Liquid Crystal Precursor: Used in the manufacture of fluorinated liquid crystals for display technologies.

Basic Information

Product Name	2-(Trifluoromethyl)Benzenesulfonyl Fluoride
CAS No.	52201-00-0
Molecular Formula	C7H4F4O2S
Molecular Weight	228.17 g/mol
Synonyms	α,α,α-Trifluoro-o-toluenesulfonyl Fluoride; 2-(Trifluoromethyl)benzene-1-sulfonyl Fluoride; o-(Trifluoromethyl)benzenesulfonyl Fluoride; Benzenesulfonyl Fluoride, 2-(trifluoromethyl)-; 2-Trifluoromethylphenylsulfonyl Fluoride
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Benzenesulfonyl Fluoride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is provided with each shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.