Description

Trifluoperazine N(4')-Oxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug trifluoperazine. This compound is of significant interest for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for metabolite identification, pharmacokinetic studies, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of trifluoperazine metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of trifluoperazine.
• Impurity Profiling: Serves as a known impurity standard in the quality control of trifluoperazine active pharmaceutical ingredient (API) to ensure product purity and safety.
• Analytical Method Development: Used to validate HPLC, LC-MS, and other chromatographic methods for the detection of phenothiazine derivatives.
• Neuroscience Research: Employed in preclinical studies to understand the mechanism of action and side-effect profile of antipsychotic agents.
• Chemical Synthesis: Acts as a specialized intermediate for the synthesis of novel phenothiazine-based compounds for research purposes.

Basic Information

Product Name	Trifluoperazine N(4')-Oxide
CAS No.	52172-25-5
Molecular Formula	C21H24F3N3OS
Molecular Weight	439.50 g/mol
Synonyms	10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine 5-oxide; Trifluoperazine Sulfoxide; Trifluoperazine S-Oxide; Trifluoperazine 5-Oxide; NSC 113929; Trifluoperazine Metabolite; SKF 6075-A; Trifluoperazine N-Oxide (common misnomer)
EINECS	Contact for details

Quality Control

Our Trifluoperazine N(4')-Oxide is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR, MS), and residual solvent analysis to ensure it meets high-purity standards suitable for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.