Description

(E)-2-(4-Chlorophenyl)Ethylenesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative essential for advanced organic synthesis. This compound serves as a critical building block for constructing complex molecules, particularly in the development of pharmaceuticals and agrochemicals. It is primarily sought after by research institutions, fine chemical manufacturers, and process development chemists working on sulfonamide-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides with sulfonylurea or sulfonamide backbones.
• Material Science Research: Building block for creating functional polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the design of activity-based probes and covalent inhibitors for target identification and validation.
• Cross-coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed and other transition metal-mediated reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	(E)-2-(4-Chlorophenyl)Ethylenesulfonyl Chloride
CAS No.	52147-98-5
Molecular Formula	C8H6Cl2O2S
Molecular Weight	237.10 g/mol
Synonyms	(E)-1-Chloro-2-[(4-chlorophenyl)ethenesulfonyl]; trans-2-(4-Chlorophenyl)ethenesulfonyl chloride; 4-Chlorostyryl sulfonyl chloride; (E)-4-Chlorostyrene-1-sulfonyl chloride; (E)-2-(p-Chlorophenyl)vinylsulfonyl chloride; (E)-β-(4-Chlorophenyl)ethenesulfonyl chloride; (E)-1-(4-Chlorophenyl)ethene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our (E)-2-(4-Chlorophenyl)Ethylenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.