Description

7,8-Didehydro-4,5α-Epoxy-17-Methyl-6α-[(Trimethylsilyl)Oxy]Morphinan-3-Yl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Trimethylsilyl Ester is a highly specialized, fully silylated derivative of a morphinan alkaloid, designed for advanced analytical and synthetic chemistry applications. This compound is critical for researchers and manufacturers requiring precise, stable reference materials for method development and quality control in regulated environments. It is primarily utilized in pharmaceutical research, forensic analysis, and the development of high-purity active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a certified analytical standard for the identification and quantification of related substances in drug development and quality control laboratories.
• Metabolite Analysis: Used in the synthesis and study of glucuronidated metabolites for pharmacokinetic and toxicological research.
• Forensic Science: Employed as a high-purity calibrant in forensic toxicology for the accurate detection and confirmation of specific alkaloids and their derivatives.
• Process Chemistry: Acts as a key synthetic intermediate or protected form in the multi-step synthesis of complex pharmaceutical compounds.
• Analytical Method Development: Essential for developing and validating sensitive chromatographic methods (GC-MS, LC-MS) due to its derivatized, volatile nature.
• Academic & Institutional Research: Supports chemical and pharmacological studies investigating the structure-activity relationships of opioid-derived molecules.

Basic Information

Product Name	7,8-Didehydro-4,5α-Epoxy-17-Methyl-6α-[(Trimethylsilyl)Oxy]Morphinan-3-Yl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Trimethylsilyl Ester
CAS No.	52092-53-2
Molecular Formula	C46H77NO11Si5
Molecular Weight	1000.6 g/mol
Synonyms	Morphine-3-β-D-glucuronide, pentakis(trimethylsilyl) ether; Morphine 3-glucuronide, per(trimethylsilyl) derivative; O6-Monoacetylmorphine-3-β-D-glucuronide, per-TMS; 3-Glucuronide of 6-Monoacetylmorphine, fully silylated; Per-TMS Morphine-3-Glucuronide; TMS Derivative of Morphine-3-Glucuronide; 17-Methyl-4,5α-epoxy-7,8-didehydro-6α-[(trimethylsilyl)oxy]morphinan-3-yl 2,3,4-tris-O-(trimethylsilyl)-β-D-glucopyranosiduronic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our production of this high-purity reference material adheres to stringent quality protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing all critical parameters, ensuring traceability and compliance with research and regulatory requirements. Specifications can be aligned with pharmacopeial standards (e.g., USP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.