Description

2,4,6-Trichloro-3,5-difluoropyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for introducing both chlorine and fluorine atoms into target molecules, enabling fine-tuning of electronic and steric properties. This compound is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly for developing novel active ingredients and complex intermediates.

Application

• Agrochemical Intermediate: A key synthon for the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Pharmaceutical Building Block: Used in the research and development of active pharmaceutical ingredients (APIs), especially in the creation of fluorinated drug candidates with improved metabolic stability and bioavailability.
• Material Science Precursor: Employed in the synthesis of specialized ligands, functionalized polymers, and advanced materials requiring specific halogenated aromatic cores.
• Cross-Coupling Reactions: Serves as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct complex biaryl systems.
• Nucleophilic Aromatic Substitution: The chlorine atoms are susceptible to displacement by various nucleophiles, allowing for the introduction of diverse functional groups onto the pyridine ring.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships (SAR) and the effects of polyhalogenation on aromatic systems in medicinal and agrochemical chemistry.

Basic Information

Product Name	2,4,6-Trichloro-3,5-difluoropyridine
CAS No.	52074-51-8
Molecular Formula	C5HCl3F2N
Molecular Weight	214.42 g/mol
Synonyms	3,5-Difluoro-2,4,6-trichloropyridine; 2,4,6-Trichloro-3,5-difluoropyridine; Pyridine, 2,4,6-trichloro-3,5-difluoro-; 3,5-Difluoro-2,4,6-trichloropyridine; 2,4,6-Trichloro-3,5-difluoropyridine; 52074-51-8 (CAS)
EINECS	Contact for details

Quality Control

Our 2,4,6-Trichloro-3,5-difluoropyridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including chromatographic purity assays and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.