Description

8-Deazafolic Acid is a synthetic analog of folic acid, specifically designed as a key intermediate in the research and development of novel therapeutic agents. Its core value lies in its structural modification, which allows scientists to investigate and develop compounds targeting folate-dependent enzymes and pathways. This makes it a critical material for pharmaceutical R&D teams and fine chemical manufacturers focused on oncology, antimicrobial, and metabolic disease research. The compound, identified by CAS NO 51989-25-4, is essential for advancing high-value medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel antifolate drugs and enzyme inhibitors.
• Biochemical Research: Used as a tool compound in studies targeting dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Anticancer Agent Development: A foundational scaffold for research into chemotherapeutic agents that disrupt DNA synthesis in rapidly dividing cells.
• Antimicrobial Research: Investigated for the development of new antibiotics and antiparasitic agents that exploit bacterial or protozoal folate metabolism.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic & Contract Research: Utilized in university and CRO settings for fundamental research in medicinal chemistry and molecular biology.

Basic Information

Product Name	8-Deazafolic Acid
CAS No.	51989-25-4
Molecular Formula	C19H19N7O6
Molecular Weight	441.40 g/mol
Synonyms	8-Deazafolic Acid; 8-Deazapteroylglutamic Acid; 5-Deaza-5,6,7,8-tetrahydropteroylglutamic Acid; NSC 154020; L-Glutamic acid, N-[4-[[(2-amino-5,6,7,8-tetrahydro-4-oxo-8-pteridinyl)methyl]amino]benzoyl]-; 8-Deazaaminopterin precursor; Folate analog intermediate
EINECS	Contact for details

Quality Control

Our 8-Deazafolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and comprehensive residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our commitment is to deliver material of consistent, high purity suitable for demanding pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.