Description

Phorbol-12,13-Dipropionate CAS NO 51821-33-1 is a specific, high-purity derivative of the phorbol ester family, a class of compounds known for their potent biological activity. This product is critical for researchers in pharmacology and toxicology, particularly for its role as a standard reference material and a key tool compound in signal transduction studies. It is primarily utilized by academic, pharmaceutical, and biotechnology R&D laboratories for investigating protein kinase C (PKC) activation pathways, tumor promotion mechanisms, and cellular response models.

Application

• Biomedical Research: As a potent activator of Protein Kinase C (PKC) isoforms for studying intracellular signaling cascades, cell proliferation, and differentiation.
• Toxicology Studies: Used as a reference standard and positive control in assays investigating tumor promotion and skin irritation mechanisms.
• Pharmacology Screening: Employed as a tool compound in high-throughput screening (HTS) to identify novel PKC inhibitors or modulators for drug discovery.
• Cell Biology: For inducing specific cellular responses in model systems to study inflammation, apoptosis, and immune cell activation.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in analytical laboratories.
• Biochemical Assay Development: Used in formulating assay kits and reagents for measuring PKC activity and related enzymatic functions.

Basic Information

Product Name	Phorbol-12,13-Dipropionate
CAS No.	51821-33-1
Molecular Formula	C29H38O8
Molecular Weight	514.61 g/mol
Synonyms	12,13-Dipropionylphorbol; Phorbol 12,13-dipropanoate; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12,13-dipropionate; TPA-DP; NSC 326322; 12-O-Tetradecanoylphorbol-13-acetate dipropionate analog; Phorbol-12,13-di-n-propionate
EINECS	Contact for details

Quality Control

Our Phorbol-12,13-Dipropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards. We support cGMP practices for advanced material production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.