Description

1-Bromo-4-Difluoromethylbenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethyl substituents, makes it a critical intermediate for introducing fluorinated motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties such as metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in drug discovery for metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial R&D focused on exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Product Name	1-Bromo-4-Difluoromethylbenzene
CAS No.	51776-71-7
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	4-Bromobenzyl Difluoride; p-Bromo(α,α-difluoro)toluene; (4-Bromophenyl)difluoromethane; 4-Bromo-α,α-difluorotoluene; 1-Bromo-4-(difluoromethyl)benzene; α,α-Difluoro-4-bromotoluene; Benzene, 1-bromo-4-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Difluoromethylbenzene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The compound is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices for halogenated and fluorinated compounds.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.