Description

2-Chloro-4-(Trifluoromethyl)Phenyl is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and a trifluoromethyl group on the phenyl ring, makes it a critical intermediate for creating molecules with tailored properties. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

2-Chloro-4-(Trifluoromethyl)Phenyl serves as a key synthetic intermediate in several high-value industrial sectors:

• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the bioisosteric and lipophilicity-enhancing trifluoromethyl group.
• Agrochemical Synthesis: A crucial building block for developing modern herbicides, fungicides, and insecticides, where the chloro- and trifluoromethyl- substituents contribute to efficacy and environmental profile.
• Liquid Crystal Materials: Employed in the production of advanced liquid crystal compounds for display technologies.
• Organic Light-Emitting Diodes (OLEDs): Acts as a precursor for electron-transport materials or host materials in OLED fabrication.
• Polymer Modification: Used to introduce functional aromatic groups into polymer chains to alter thermal stability, solubility, or electronic properties.
• General Organic Synthesis: Serves as a versatile starting material for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to create complex, functionalized arenes.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Phenyl
CAS No.	51488-22-3
Molecular Formula	C7H4ClF3
Molecular Weight	180.55 g/mol
Synonyms	1-Chloro-2-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluorotoluene; 2-Chlorobenzotrifluoride; 2-Chloro-α,α,α-trifluoromethylbenzene; o-Chlorobenzotrifluoride; 2-Chlorophenyltrifluoromethane; (2-Chlorophenyl)trifluoromethane; 2-Chloro-1-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Phenyl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is 2-25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.