Description

Alrestatin is a potent and selective aldose reductase inhibitor, a key compound for advanced biochemical and pharmaceutical research. Its primary value lies in its ability to modulate sugar metabolism pathways, making it a critical tool for investigating diabetic complications and related metabolic disorders. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced drug candidates targeting diabetic neuropathy, retinopathy, and nephropathy.
• Biochemical Research: Used as a reference standard and investigative tool in enzymatic studies of the polyol pathway and aldose reductase activity.
• Metabolic Disorder Studies: Employed in preclinical research to understand and model the biochemical mechanisms underlying sugar alcohol accumulation and oxidative stress.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the production of high-value, target-specific chemical entities in contract research and manufacturing.

Basic Information

Product Name	Alrestatin
CAS No.	51411-04-2
Molecular Formula	C13H12N2O4S
Molecular Weight	292.31 g/mol
Synonyms	Alrestatin; 2,7-Difluorospiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione; 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-acetic acid; AY-22,284; Spiro[fluorene-9,4'-imidazolidine]-2',5'-dione, 2,7-difluoro-; Tolrestat impurity standard; Aldose reductase inhibitor.
EINECS	Contact for details

Quality Control

Our Alrestatin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.