Description

N'-Nitro-L-Arginine-Methyl Ester Hydrochloride is a high-purity, chemically defined derivative of L-arginine, widely recognized as a potent and selective inhibitor of nitric oxide synthase (NOS). This compound is critical for research and development in life sciences, providing a reliable tool for modulating the NO signaling pathway in experimental models. It is essential for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on cardiovascular, neurological, and inflammatory disease mechanisms.

Application

• Nitric Oxide Synthase (NOS) Inhibition Research: A standard research chemical for in vitro and in vivo studies to investigate the physiological and pathological roles of nitric oxide.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) in the development and quality control of novel NOS-targeting therapeutics.
• Biochemical Assay Development: Serves as a key component in high-throughput screening (HTS) assays to identify new drug candidates.
• Academic & Clinical Research: Fundamental tool for studying vascular tone, neurotransmission, immune response, and related cellular signaling pathways.
• Preclinical Disease Modeling: Used to create experimental models of conditions like hypertension, sepsis, and neurodegeneration by inhibiting NO production.

Basic Information

Product Name	N'-Nitro-L-Arginine-Methyl Ester Hydrochloride
CAS No.	51298-62-5
Molecular Formula	C7H15N5O4 • HCl
Molecular Weight	269.68 g/mol
Synonyms	L-NAME hydrochloride; Nω-Nitro-L-arginine methyl ester hydrochloride; NG-Nitro-L-arginine methyl ester hydrochloride; Nitro-L-arginine methyl ester HCl; L-NG-Nitroarginine methyl ester hydrochloride; N5-[Imino(nitroamino)methyl]-L-ornithine methyl ester hydrochloride; (S)-2-Amino-5-[(aminoiminomethyl)nitroamino]pentanoic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our N'-Nitro-L-Arginine-Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-20° to -24° (c=1 in H2O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.