Description

Ethacrynic Acid L-Cysteine Adduct is a specialized pharmaceutical intermediate formed by the covalent conjugation of ethacrynic acid with the amino acid L-cysteine. This compound is of significant interest in medicinal chemistry and drug development due to its role as a model for studying drug-protein interactions and as a precursor for targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel diuretics, anti-cancer therapies, and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates and targeted prodrugs.
• Biochemical Research: Used as a tool compound to study glutathione S-transferase (GST) inhibition and redox biology.
• Medicinal Chemistry: Acts as a precursor for developing covalent inhibitors that target specific cysteine residues in proteins.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Preclinical Development: Utilized in in vitro and in vivo studies to investigate pharmacokinetics and metabolism of ethacrynic acid derivatives.

Basic Information

Product Name	Ethacrynic Acid L-Cysteine Adduct
CAS No.	51246-37-8
Molecular Formula	C16H19NO6S
Molecular Weight	353.39 g/mol
Synonyms	Ethacrynic Acid-Cysteine Adduct; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic Acid S-(2-Amino-2-carboxyethyl) Ester; Ethacrynic Acid Cysteine Conjugate; Edecrin-Cysteine Adduct; (2R)-2-Amino-3-[[[2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetyl]oxy]sulfanyl]propanoic Acid; L-Cysteine Ethacrynic Acid Ester; GST Inhibitor Model Compound
EINECS	Contact for details

Quality Control

Our Ethacrynic Acid L-Cysteine Adduct is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and identity confirmation by spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high-purity and well-characterized biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.