Description

5-Fluoro-2-Hydroxypyridine is a versatile fluorinated pyridine derivative, a key heterocyclic building block prized for its unique electronic and steric properties. Its value lies in enabling the synthesis of complex molecules with enhanced biological activity and material characteristics. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drugs targeting central nervous system disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the fluorine atom improves metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing character.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a biochemical probe.
• Custom Synthesis and R&D: A fundamental reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies.

Basic Information

Product Name	5-Fluoro-2-Hydroxypyridine
CAS No.	51173-05-8
Molecular Formula	C5H4FNO
Molecular Weight	113.09 g/mol
Synonyms	5-Fluoro-2-pyridinol; 5-Fluoro-2(1H)-pyridinone; 2-Hydroxy-5-fluoropyridine; 5-Fluoropyridin-2-ol; 5-Fluoro-1H-pyridin-2-one; 5-Fluoro-2-oxo-1,2-dihydropyridine; 5-Fluoropyridin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Hydroxypyridine is manufactured under strict quality management systems. We provide material with typical purity levels of ≥98% (HPLC), suitable for demanding R&D and scale-up applications. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment ensures reliable, batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.