Description

2,6-Di-o-Methyl-α-Cyclodextrin is a chemically modified derivative of α-cyclodextrin, featuring selective methylation at the 2- and 6-positions of the glucose units. This modification significantly enhances its solubility in water and organic solvents compared to the parent compound, making it a superior host molecule for forming inclusion complexes. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require advanced molecular encapsulation to improve the solubility, stability, and bioavailability of active ingredients.

Application

• Pharmaceutical Formulation: Used as a solubility enhancer and stabilizer for poorly water-soluble drugs in oral and injectable formulations.
• Analytical Chemistry: Serves as a chiral selector in capillary electrophoresis and HPLC for the separation of enantiomers.
• Catalysis: Acts as a supramolecular catalyst or co-catalyst in organic synthesis, facilitating reactions within its hydrophobic cavity.
• Agrochemical Delivery: Employed in pesticide and herbicide formulations to enhance stability, reduce volatility, and control release.
• Flavor & Fragrance Encapsulation: Protects sensitive aroma compounds from oxidation and evaporation in food and cosmetic products.
• Material Science: Utilized in the development of functional polymers, sensors, and nano-carriers for targeted delivery systems.

Basic Information

Product Name	2,6-Di-o-Methyl-α-Cyclodextrin
CAS No.	51166-72-4
Molecular Formula	C48H80O40
Molecular Weight	1185.12 g/mol
Synonyms	2,6-Di-O-Methyl-α-Cyclodextrin; Heptakis(2,6-di-O-methyl)-α-cyclodextrin; 2,6-Dimethyl-α-cyclodextrin; DIMEA; Randomly methylated α-cyclodextrin (partial); α-CD-2,6-DM; Cycloheptaamylose 2,6-dimethyl ether; Hexadeca-O-methyl-α-cyclodextrin (theoretical fully methylated form)
EINECS	Contact for details

Quality Control

Our 2,6-Di-o-Methyl-α-Cyclodextrin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and degree of substitution (DS) analysis, to ensure it meets the high standards required for research and industrial applications. A Certificate of Analysis (COA) detailing identity, purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture, which can affect product quality and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Degree of Substitution (DS)	~1.8 - 2.0 per glucose unit
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Specific Rotation	+150° to +165° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.