Description

Aphidicolin-17-Monoacetate is a chemically modified derivative of the natural tetracyclic diterpenoid, aphidicolin. This compound is a crucial biochemical tool, primarily valued for its potent and specific inhibition of eukaryotic DNA polymerases, particularly DNA polymerase α. It is essential for researchers and manufacturers in the life sciences sector, including those in molecular biology, virology, and oncology research, where it is used to study cell cycle progression, DNA replication, and as a selective agent in various assays.

Application

• Molecular Biology Research: A key reagent for synchronizing eukaryotic cells in the G1/S phase by inhibiting nuclear DNA replication.
• Virology Studies: Used to investigate the replication mechanisms of DNA viruses and to distinguish between viral and host DNA polymerase activity.
• Cancer Research: Employed in studies of cell cycle checkpoints, apoptosis, and the screening of anti-proliferative compounds.
• Biochemical Assays: Serves as a specific inhibitor in enzymatic assays to characterize DNA polymerase families and their functions.
• Pharmaceutical Intermediates: Acts as a sophisticated starting material or reference standard in the development of novel therapeutic agents.
• Cell Culture & Cytotoxicity Studies: Utilized to induce reversible cell cycle arrest for studying cellular responses and compound toxicity.

Basic Information

Product Name	Aphidicolin-17-Monoacetate
CAS No.	51103-57-2
Molecular Formula	C24H34O6
Molecular Weight	418.53 g/mol
Synonyms	Aphidicolin 17-Acetate; 17-Monoacetylaphidicolin; Aphidicolin-17-acetate; NSC 234714; (3R,4aR,5S,6aS,10aS,10bR)-5-(Acetyloxy)-3,4a,7,7,10a-pentamethyl-1-oxo-1,3,4,4a,5,6,6a,10,10a,10b-decahydro-2H-benzo[f]chromen-8-yl acetate
EINECS	Contact for details

Quality Control

Our Aphidicolin-17-Monoacetate is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications and results is provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.