Description

o-Desmethyl-n-Deschlorobenzoyl Indomethacin is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) indomethacin. This compound is of significant value for research and development in pharmacology and analytical chemistry, particularly in drug metabolism and pharmacokinetic (DMPK) studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for analytical method development and validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and qualification of indomethacin and its metabolites in biological matrices.
• Drug Metabolism Studies: Critical for investigating the metabolic pathways, bioavailability, and clearance mechanisms of indomethacin in preclinical and clinical research.
• Analytical Method Development: Used as a high-purity standard to develop and validate sensitive HPLC, LC-MS, or GC-MS methods for bioanalysis.
• Impurity Profiling: Employed in the identification and control of potential degradants or process-related impurities in indomethacin API manufacturing.
• Pharmacological Research: A tool for studying the structure-activity relationship (SAR) of indomethacin analogs to understand efficacy and toxicity.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with FDA, EMA) requiring detailed characterization of drug metabolites.

Basic Information

Product Name	o-Desmethyl-n-Deschlorobenzoyl Indomethacin
CAS No.	50995-53-4
Molecular Formula	C18H14ClNO4
Molecular Weight	343.76 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid; Desmethyl Deschlorobenzoyl Indomethacin; 2-Desmethyl-Desbenzoyl Indomethacin; Indomethacin Metabolite; 5-Methoxy-2-methyl-1-(4-chlorobenzoyl)indol-3-ylacetic Acid; 3-Carboxymethyl-5-methoxy-2-methylindole-1-(4-chlorobenzoyl); NSC 339539
EINECS	Contact for details

Quality Control

Our o-Desmethyl-n-Deschlorobenzoyl Indomethacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity assay by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.