Description

Wy-14643 is a potent and selective agonist for the peroxisome proliferator-activated receptor alpha (PPARα), widely utilized as a key research tool in metabolic and cardiovascular studies. Its high specificity makes it invaluable for investigating lipid metabolism, glucose homeostasis, and inflammatory pathways in preclinical models. This compound is essential for pharmaceutical R&D, academic research, and biotechnology sectors focused on developing novel therapeutics for metabolic disorders.

Application

• Pharmacological Research: A standard reference agonist for studying PPARα receptor activation, signaling, and downstream gene expression.
• Metabolic Disease Models: Used to induce and study mechanisms in models of dyslipidemia, fatty liver disease, and type 2 diabetes.
• Cardiovascular Research: Employed in research exploring the role of PPARα in atherosclerosis, inflammation, and vascular function.
• Biomarker Discovery: Facilitates the identification and validation of novel biomarkers associated with PPARα pathway modulation.
• Drug Screening & Development: Serves as a positive control in high-throughput screening assays for novel PPARα modulators.
• Academic & Institutional Studies: Fundamental tool for basic science research in biochemistry, molecular biology, and physiology.

Basic Information

Product Name	Wy-14643
CAS No.	50892-23-4
Molecular Formula	C₁₅H₁₅NO₄
Molecular Weight	273.28 g/mol
Synonyms	Pirinixic Acid; 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid; WY 14,643; WY-14,643; WY 14643; PPARα Agonist WY-14643; [4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thioacetic Acid
EINECS	Contact for details

Quality Control

Our Wy-14643 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.