Description

4-(Trifluoromethoxy)Benzyl Bromide is a versatile and high-value organobromide building block, essential for introducing the 4-(trifluoromethoxy)benzyl moiety into complex molecular architectures. Its primary commercial value lies in enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the trifluoromethoxy group imparts desirable metabolic stability and lipophilicity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: Reacts with various nucleophiles (amines, thiols, alkoxides) to create functionalized benzyl derivatives for further chemical elaboration.
• Polymer Chemistry: Monomer or modifier for introducing fluorine-containing aromatic units into specialty polymers to alter thermal and surface properties.

Basic Information

Product Name	4-(Trifluoromethoxy)Benzyl Bromide
CAS No.	50824-05-0
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	α-Bromo-4-(trifluoromethoxy)toluene; 1-(Bromomethyl)-4-(trifluoromethoxy)benzene; (4-(Trifluoromethoxy)phenyl)methyl bromide; p-(Trifluoromethoxy)benzyl bromide; 4-(Trifluoromethoxy)phenylmethyl Bromide; 4-(Trifluoromethoxy)-α-bromotoluene; 4-(Trifluoromethoxy)benzylbromide
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical applications, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.