Description

N2'-Deacetyl-15-Hydroxy-N2'-(2-Methyl-1-Oxopropyl)Maytansine is a potent maytansinoid derivative, a class of compounds renowned for their microtubule-disrupting and cytotoxic activities. This compound serves as a critical intermediate and payload in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is essential for pharmaceutical R&D teams, process chemists, and manufacturers focused on creating next-generation oncology therapeutics, where its precise structure enables the construction of highly specific and efficacious drug conjugates.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary application as a cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer treatment.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel anti-cancer agents.
• Bioconjugation Chemistry: Serves as a key intermediate for developing novel linker-payload technologies to optimize ADC stability, potency, and therapeutic index.
• Mechanistic Studies: Employed in biochemical assays to study microtubule dynamics, cell cycle arrest, and mechanisms of induced apoptosis.
• Process Development & Scale-Up: Critical for pharmaceutical companies scaling up the synthesis of ADC candidates from milligram to gram quantities.

Basic Information

Product Name	N2'-Deacetyl-15-Hydroxy-N2'-(2-Methyl-1-Oxopropyl)Maytansine
CAS No.	50657-33-5
Molecular Formula	C34H46ClN3O9
Molecular Weight	676.20 g/mol
Synonyms	DM1; Mertansine; Maytansinoid DM1; Ansamitocin P-3 derivative; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine precursor; NSC 330507; (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-((2S,3S)-2-methyl-1-oxo-3-((2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl)butyl)amino)-3-oxopropyl)oxy)-14-oxo-6-(((2R,3R)-3-((2S,3S)-3-(acetyloxy)-2-methylbutanoyl)oxy)-2-methyloxiran-2-yl)methyl)-1-oxa-14-azacyclotetradecane-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our N2'-Deacetyl-15-Hydroxy-N2'-(2-Methyl-1-Oxopropyl)Maytansine is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for ADC payload synthesis and biomedical research. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-controlled environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.