Description

Demethylcotinine is a significant metabolite of nicotine, offering a valuable analytical standard and research chemical for the life sciences. Its importance lies in its role as a biomarker for nicotine metabolism and as a key intermediate in the study of nicotinic pharmacology. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and analytical chemistry sectors who require high-purity reference materials.

Application

• Pharmaceutical Research: Used as a key intermediate and reference standard in the development and study of drugs targeting nicotinic acetylcholine receptors.
• Biomarker Analysis: Serves as a critical analytical standard in clinical and forensic toxicology for quantifying nicotine exposure and metabolic rates.
• Diagnostic Kit Manufacturing: Employed in the production of calibration standards and controls for immunoassays and LC-MS/MS kits designed to measure nicotine metabolites.
• Metabolic Pathway Studies: Utilized in academic and industrial research to investigate the pharmacokinetics and pharmacodynamics of nicotine and related alkaloids.
• Quality Control Reference: Acts as a certified reference material (CRM) for ensuring the accuracy and precision of analytical methods in contract research organizations (CROs) and quality control labs.

Basic Information

Product Name	Demethylcotinine
CAS No.	5980-06-3
Molecular Formula	C9H10N2O
Molecular Weight	162.19 g/mol
Synonyms	5-(3-Pyridinyl)-1-pyrrolidin-2-one; Norcotinine; Nornicotine; 1-(3-Pyridinyl)-2-pyrrolidinone; Demethylcotinine; Cotinine metabolite; 2-Oxo-1-(3-pyridinyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our Demethylcotinine is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analysis, including identity confirmation, purity assay, and impurity profiling via advanced chromatographic techniques. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.