Description

Pth-Serine is a protected derivative of the amino acid L-serine, where the amine group is blocked by a phthaloyl (Pth) protecting group. This modification is critical for enabling selective peptide bond formation during complex organic synthesis, particularly in peptide and pharmaceutical manufacturing. It is an essential building block for researchers and production chemists in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require high-purity intermediates for reliable and reproducible results.

Application

• Peptide Synthesis: Serves as a key protected intermediate in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods to prevent unwanted side reactions.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Biochemical Research: Employed in studies involving amino acid metabolism, enzyme substrates, and the synthesis of custom amino acid analogs.
• Fine Chemical Production: Acts as a chiral building block for the synthesis of complex organic molecules, including natural products and specialty chemicals.
• Protecting Group Chemistry: Utilized in multi-step synthetic routes where selective deprotection of functional groups is required.

Basic Information

Product Name	Pth-Serine
CAS No.	5789-22-0
Molecular Formula	C11H9NO5
Molecular Weight	235.19 g/mol
Synonyms	N-Phthaloyl-L-serine; (S)-2-(1,3-Dioxoisoindolin-2-yl)-3-hydroxypropanoic acid; Phthaloylserine; L-Serine, N-phthaloyl-; 2-[(3S)-3-Hydroxy-1-oxopropoxy]-1H-isoindole-1,3(2H)-dione
EINECS	227-324-5

Quality Control

Our Pth-Serine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability, consistency, and compliance with your research or production protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-30° to -35° (c=1 in DMF)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.