Description

4-Hydroxytolbutamide is a key pharmaceutical intermediate and metabolite of the sulfonylurea drug Tolbutamide. This compound matters for its critical role in drug metabolism studies and the synthesis of advanced pharmaceutical agents. It is primarily needed by research institutions and pharmaceutical manufacturers focused on diabetes research, analytical method development, and the production of high-purity reference standards.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of sulfonylurea-based drugs and related compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical and pharmacokinetic studies for Tolbutamide metabolism.
• Biochemical Research: Employed in studies investigating drug metabolism pathways, enzyme interactions, and diabetes-related mechanisms.
• Analytical Chemistry: Serves as a high-purity calibrant or internal standard in HPLC, LC-MS, and other chromatographic methods.
• Quality Control Laboratories: Utilized for method validation and impurity profiling in pharmaceutical quality assurance.

Basic Information

Item	Details
Product Name	4-Hydroxytolbutamide
CAS No.	5719-85-7
Molecular Formula	C₁₂H₁₈N₂O₄S
Molecular Weight	286.35 g/mol
Synonyms	1-Butyl-3-(4-hydroxyphenyl)sulfonylurea; 4-Hydroxy-1-butyl-3-(p-tolylsulfonyl)urea; Hydroxytolbutamide; Tolbutamide Metabolite; 4-Hydroxy Tolbutamide; 4-OH-Tolbutamide; p-Hydroxytolbutamide; N-(Butylcarbamoyl)-4-hydroxybenzenesulfonamide
EINECS	Contact for details

Quality Control

Our 4-Hydroxytolbutamide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.