Description

(±)-2-Amino-3-Phosphonopropionic Acid (AP-3) is a potent and selective competitive antagonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. This compound is a critical research tool for neuroscientists studying excitatory neurotransmission, synaptic plasticity, and the pathophysiology of neurological disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and central nervous system drug discovery.

Application

• Neuroscience Research: A fundamental pharmacological tool for selectively blocking NMDA receptor activity in in vitro and ex vivo experimental models to study excitotoxicity, long-term potentiation (LTP), and synaptic signaling.
• Neuropharmacology Screening: Used as a reference standard and active control in high-throughput screening assays designed to identify novel NMDA receptor modulators and neuroprotective agents.
• Disease Mechanism Studies: Critical for investigating the role of glutamate excitotoxicity in conditions such as stroke, traumatic brain injury, epilepsy, and neurodegenerative diseases like Alzheimer's and Parkinson's.
• Biochemical Assay Development: Serves as a key component in developing and validating receptor binding assays and functional cell-based assays for NMDA receptor characterization.
• Academic & Clinical Research: Supports basic science and translational research projects in university and hospital settings aimed at understanding glutamate receptor function.

Basic Information

Item	Detail
Product Name	(±)-2-Amino-3-Phosphonopropionic Acid (AP-3) NMDA Antagonist
CAS No.	5652-28-8
Molecular Formula	C₃H₈NO₅P
Molecular Weight	169.07 g/mol
Synonyms	AP-3; (±)-AP-3; DL-2-Amino-3-phosphonopropionic acid; DL-AP3; DL-2-Amino-4-phosphonobutanoic acid (common misnomer); 2-Amino-3-phosphonopropanoic acid; NMDA receptor antagonist AP-3; (RS)-2-Amino-3-phosphonopropionic acid
EINECS	Contact for details

Quality Control

Our (±)-2-Amino-3-Phosphonopropionic Acid is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, essential for reproducible research outcomes. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, dilute acids and bases

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.