Description

8-Hydroxyguanine is a significant oxidized derivative of guanine, a key nucleobase in DNA and RNA. This compound is of critical importance in biochemical research as a biomarker for oxidative stress and DNA damage studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on aging, carcinogenesis, and cellular metabolism.

Application

• Biomarker Research: Used as a standard and probe in studies quantifying oxidative DNA damage and evaluating the efficacy of antioxidants.
• Pharmaceutical Development: Employed in the research and screening of novel therapeutic agents designed to mitigate oxidative stress-related pathologies.
• Diagnostic Assay Development: Serves as a critical reference material in the development of ELISA kits, LC-MS/MS methods, and other assays for detecting DNA lesions.
• Toxicology Studies: Applied in environmental and industrial toxicology to assess genotoxic effects of chemicals, radiation, and other stressors.
• Academic Research: Fundamental tool in university and institutional labs studying mechanisms of DNA repair, mutagenesis, and free radical biology.

Basic Information

Product Name	8-Hydroxyguanine
CAS No.	5614-64-2
Molecular Formula	C5H5N5O2
Molecular Weight	167.13 g/mol
Synonyms	8-Oxo-7,8-dihydroguanine; 8-OH-Gua; 8-Oxoguanine; 7,8-Dihydro-8-oxoguanine; 8-Hydroxy-2'-deoxyguanosine precursor; Oxidative guanine lesion; GO
EINECS	Contact for details

Quality Control

Our 8-Hydroxyguanine is produced under stringent quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and quality standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.