Description

Tyrphostin A63 CAS NO 5553-97-9 is a potent and selective inhibitor of protein tyrosine kinases, specifically targeting the epidermal growth factor receptor (EGFR). This compound matters as a critical research tool for elucidating signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer research, kinase inhibitor development, and cellular signaling studies.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study signal transduction mechanisms in vitro and in cell-based assays.
• Cancer Research: Investigated for its effects on tumor cell growth, proliferation, and apoptosis in various cancer models, particularly those driven by EGFR signaling.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool in high-throughput screening and lead optimization for novel kinase-targeted therapeutics.
• Cellular Signaling Studies: Employed to dissect the role of specific tyrosine kinases in cellular processes like differentiation, migration, and survival.
• Academic & Institutional Research: A key reagent for fundamental research in molecular biology, pharmacology, and cell biology departments.

Basic Information

Product Name	Tyrphostin A63
CAS No.	5553-97-9
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 63; Tyrphostin AG 63; 2-[(2,4-Dihydroxyphenyl)methylene]malononitrile; 2-[(2,4-Dihydroxybenzylidene)]malononitrile; 2-(2,4-Dihydroxybenzylidene)malononitrile; EGFR Tyrosine Kinase Inhibitor AG 63; RG 50810; RG-50810; NSC 654705
EINECS	Contact for details

Quality Control

Our Tyrphostin A63 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling. A Certificate of Analysis (COA) detailing the specific results for your batch is provided to guarantee it meets the stringent requirements of laboratory and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.