Description

3-Fluoro-4-Chlorotoluene is a versatile halogenated toluene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive aromatic scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This intermediate is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), especially those requiring fluorinated and chlorinated aromatic motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents contribute to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a starting material for synthesizing fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, which require precise halogen substitution patterns.
• Polymer & Resin Modifiers: Employed to introduce halogenated phenyl groups into polymer chains, modifying properties like flame retardancy, thermal stability, and chemical resistance.
• Dyestuff & Pigment Intermediate: Acts as a building block for producing halogenated dyes and pigments, offering improved lightfastness and color properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating complex biaryl structures common in advanced materials.

Basic Information

Product Name	3-Fluoro-4-Chlorotoluene
CAS No.	5527-94-6
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	1-Chloro-2-fluoro-4-methylbenzene; 4-Chloro-3-fluorotoluene; 2-Fluoro-4-methylchlorobenzene; 3-Fluoro-4-chloro-1-methylbenzene; Toluene, 3-fluoro-4-chloro-; 4-Methyl-2-fluorochlorobenzene; Benzene, 1-chloro-2-fluoro-4-methyl-; 3-Fluoro-p-chlorotoluene
EINECS	226-863-6

Quality Control

Our 3-Fluoro-4-Chlorotoluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.2%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Density (20°C)	~1.25 g/cm³
Boiling Point	~185-190°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.