Description

Digoxigenin-Bis(Digitoxoside) CAS NO 5297-05-2 is a specialized cardiac glycoside derivative, a key intermediate in the synthesis of digoxin and related compounds. Its precise chemical structure makes it an invaluable reference standard and building block for pharmaceutical research and development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, well-characterized materials for analytical method development, quality control, and novel drug synthesis.

Application

• Pharmaceutical Reference Standard: Used as a primary or secondary standard for the quantitative and qualitative analysis of digoxin and related cardiac glycosides via HPLC, LC-MS, and other chromatographic methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical synthetic precursor in the multi-step manufacturing process of digoxin and its analogs.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR), metabolism, and mechanism of action of cardiac glycosides.
• Diagnostic Reagent Development: Utilized in the formulation of calibration kits and immunoassays for therapeutic drug monitoring (TDM) of digoxin levels in patient serum.
• Academic & Contract Research: Provides a well-defined starting material for medicinal chemistry programs and pharmacological studies targeting heart failure treatments.

Basic Information

Product Name	Digoxigenin-Bis(Digitoxoside)
CAS No.	5297-05-2
Molecular Formula	C₄₁H₆₄O₁₃
Molecular Weight	764.94 g/mol
Synonyms	Digoxigenin bisdigitoxoside; 3β-[(2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide; Digoxigenin-β-D-digitoxoside-(1→4)-β-D-digitoxoside; Strophanthidin 3-O-(β-D-digitoxosyl-(1→4)-β-D-digitoxoside); Digoxigenin bis-digitoxoside; Digoxigenin-β-D-bisdigitoxoside
EINECS	Contact for details

Quality Control

Our Digoxigenin-Bis(Digitoxoside) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC and NMR. We are committed to meeting the stringent requirements of pharmaceutical reference standard and intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.