Description

n-Oxalyl Glycine is a potent and selective cell-permeable inhibitor of 2-oxoglutarate-dependent dioxygenases, including prolyl hydroxylase domain (PHD) enzymes and histone demethylases. This compound matters as a critical research tool for studying hypoxia-inducible factor (HIF) signaling pathways, epigenetic regulation, and cellular responses to oxygen tension. It is needed by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, cancer research, and the investigation of metabolic and neurological disorders.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of HIF-PHD enzymes in cellular oxygen sensing and adaptation.
• Epigenetics & Cancer Research: Investigates the function of JmjC-domain containing histone demethylases in gene expression regulation and oncogenesis.
• Drug Discovery: Serves as a lead compound or pharmacological tool for developing novel therapeutics targeting hypoxia-related pathways.
• Neuroscience Studies: Explores the impact of metabolic pathways on neuronal function and survival in conditions like stroke and neurodegenerative diseases.
• Cell Culture & In Vitro Assays: Applied in experimental models to induce a pseudo-hypoxic state and study downstream gene expression.

Basic Information

Product Name	n-Oxalyl Glycine
CAS No.	5262-39-5
Molecular Formula	C4H5NO5
Molecular Weight	147.09 g/mol
Synonyms	Oxalylglycine; N-Oxalylglycine; (2S)-2-(Oxalylamino)acetic Acid; L-N-Oxalylglycine; NSC 683551; 2-[(Oxalyl)amino]acetic Acid; HIF-PHD Inhibitor; JmjC Inhibitor; OG-L; Oxalyl-Gly-OH
EINECS	226-067-7

Quality Control

Our n-Oxalyl Glycine is manufactured under strict quality controls to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.