Description

Dl-Buthionine-[S,R]-Sulfoximine is a potent and selective inhibitor of γ-glutamylcysteine synthetase, a key enzyme in the glutathione biosynthesis pathway. This compound is a critical research tool for studying cellular oxidative stress, redox biology, and the role of glutathione in chemoresistance and apoptosis. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity biochemical reagents for mechanistic studies and drug discovery programs.

Application

• Biochemical Research: Used as a standard inhibitor to deplete intracellular glutathione levels in cell culture and animal models.
• Cancer Research: Investigates mechanisms of chemosensitization and overcoming drug resistance in tumor cells.
• Neurodegenerative Disease Studies: Applied in models of Parkinson's, Alzheimer's, and other disorders linked to oxidative stress.
• Toxicology & Pharmacology: Serves as a tool compound to study the detoxification pathways and hepatotoxicity.
• Apoptosis & Cell Death Assays: Used to induce oxidative stress and study programmed cell death mechanisms.
• Antioxidant Defense System Analysis: Fundamental for research into cellular defense mechanisms against reactive oxygen species (ROS).

Basic Information

Product Name	Dl-Buthionine-[S,R]-Sulfoximine
CAS No.	5072-26-4
Molecular Formula	C8H18N2O3S
Molecular Weight	222.30 g/mol
Synonyms	DL-Buthionine sulfoximine; BSO; Buthionine Sulfoximine; (RS)-Buthionine Sulfoximine; L-Buthionine-(S,R)-sulfoximine; Buthionine Sulfoxamine; NSC 326231; γ-Glutamylcysteine Synthetase Inhibitor
EINECS	Contact for details

Quality Control

Our Dl-Buthionine-[S,R]-Sulfoximine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.