Description

Pth-Isoleucine CAS NO 5066-94-4 is a protected derivative of the essential amino acid isoleucine, where the amine group is shielded by a phthaloyl (Pth) group. This chemical modification is critical for enabling selective peptide synthesis and advanced organic transformations in research and development. It serves as a vital building block for pharmaceutical chemists, biochemists, and research scientists engaged in the synthesis of peptides, peptidomimetics, and novel bioactive compounds.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis, where the Pth group acts as a temporary protecting group for the α-amino function.
• Pharmaceutical Research: Used in the R&D of new therapeutic peptides, hormone analogs, and drug candidates that require specific, protected amino acid precursors.
• Biochemical Studies: Employed in the study of enzyme-substrate interactions and the structure-activity relationships (SAR) of peptide-based molecules.
• Organic Synthesis: Serves as a chiral building block for the asymmetric synthesis of complex natural products and non-proteinogenic amino acid derivatives.
• Proteomics & Molecular Biology: Utilized in the design and synthesis of specialized probes, inhibitors, and substrates for studying protein function and interactions.

Basic Information

Product Name	Pth-Isoleucine
CAS No.	5066-94-4
Molecular Formula	C₁₄H₁₅NO₄
Molecular Weight	261.27 g/mol
Synonyms	N-Phthaloyl-L-isoleucine; (2S,3S)-2-(1,3-Dioxoisoindolin-2-yl)-3-methylpentanoic acid; L-Isoleucine, N-phthaloyl-; Phthaloyl isoleucine; PTH-Ile; N-Pth-Isoleucine; N-Phthalimido-L-isoleucine; 2-[(3S)-3-Methyl-1-oxopentyl]isoindole-1,3-dione
EINECS	225-761-8

Quality Control

Our Pth-Isoleucine is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.