Description

Oligomycin A is a potent, macrocyclic polyketide antibiotic isolated from *Streptomyces* species, widely recognized as a specific inhibitor of mitochondrial ATP synthase (Complex V). This compound is a critical research tool for studying cellular bioenergetics, oxidative phosphorylation, and apoptosis pathways. It is essential for researchers and manufacturers in the fields of biochemistry, molecular biology, and pharmaceutical development, where precise modulation of mitochondrial function is required.

Application

• Biochemical Research: A primary tool for inhibiting the F0 subunit of ATP synthase, used to study mitochondrial respiration, proton gradients, and cellular energy metabolism.
• Cancer Research: Investigated for its ability to induce apoptosis in cancer cells by disrupting mitochondrial membrane potential and ATP production.
• Neurodegenerative Disease Models: Used in research models to simulate mitochondrial dysfunction associated with conditions like Parkinson's and Alzheimer's disease.
• Cardiovascular Research: Applied in studies of ischemia-reperfusion injury to understand the role of mitochondrial permeability transition pores.
• Antifungal Studies: Serves as a reference compound in microbiological assays due to its antifungal activity against various yeast and filamentous fungi.
• Pharmacology & Toxicology: Utilized to assess drug-induced mitochondrial toxicity and screen for compounds that can reverse oligomycin-induced cytotoxicity.

Basic Information

Product Name	Oligomycin A
CAS No.	579-13-5
Molecular Formula	C45H74O11
Molecular Weight	791.07 g/mol
Synonyms	Oligomycin A; 28,34-Epoxy-3,7,11,15,19,23,27,31-octamethyl-32,33,34,35,36,37-hexahydro-2H-oxacyclooctatriaconta-4,8,12,16,20,24,28,30,33-nonaene-5,9,13,17,21,25-hexone; Oligomycin; Oligomycin A from Streptomyces diastatochromogenes; Antibiotic 1797; NSC 131233; UNII-5U60P7SE5R
EINECS	209-424-2

Quality Control

Our Oligomycin A is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental results for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.