Description

Methanesulfonyl Fluoride is a versatile organosulfur reagent primarily used as a selective fluorinating and sulfonylating agent. Its high reactivity and selectivity make it a critical building block in advanced chemical synthesis, enabling the efficient introduction of fluorine and methanesulfonyl groups. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of fluorinated drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used to create fluorinated pesticides and herbicides with enhanced biological activity and stability.
• Peptide Chemistry: Employed as a coupling agent and for the protection/deprotection of functional groups during peptide synthesis.
• Material Science: Serves as a precursor for modifying polymer surfaces and creating specialty fluorinated materials.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-sulfur and carbon-fluorine bonds.
• Bioconjugation: Utilized for labeling biomolecules such as proteins and antibodies with fluorophores or other probes.

Basic Information

Product Name	Methanesulfonyl Fluoride
CAS No.	558-25-8
Molecular Formula	CH3FO2S
Molecular Weight	98.10 g/mol
Synonyms	Methanesulfonic acid fluoride; Mesyl fluoride; Methylsulfonyl fluoride; Fluoromethanesulfonate; MSF; FSO2Me; Fluoromethanesulfonic acid; Methanesulfonylfluorid
EINECS	209-199-7

Quality Control

Our Methanesulfonyl Fluoride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including assay (by GC/HPLC), identity confirmation (IR, NMR), and impurity profiling, to ensure it meets the high-purity standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.42 g/mL
Refractive Index (n20/D)	~1.382

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.