Description

2,4-Dinitrobenzenesulfenyl Chloride is a specialized electrophilic sulfenylating agent used in organic synthesis. This compound is valued for its ability to introduce the 2,4-dinitrophenylsulfenyl (DnpS) group, a versatile protecting group and reagent in the construction of complex molecules. It is primarily sought by research and development laboratories in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing sulfenyl groups in the development of new drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as a selective protecting group for cysteine thiols during solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific sulfur-containing functionalities.
• Material Science: Serves as a building block for creating functionalized polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme mechanisms and protein functions.
• Cross-coupling Reactions: Acts as an electrophilic partner in transition metal-catalyzed cross-coupling reactions to form carbon-sulfur bonds.

Basic Information

Product Name	2,4-Dinitrobenzenesulfenyl Chloride
CAS No.	528-76-7
Molecular Formula	C6H3ClN2O4S
Molecular Weight	234.62 g/mol
Synonyms	2,4-Dinitrobenzenesulfonyl Chloride (common error); 2,4-Dinitrophenylsulfenyl Chloride; 1-Chloro-2,4-dinitrobenzenesulfenyl; DNPS-Cl; Benzenesulfenyl chloride, 2,4-dinitro-; (2,4-Dinitrophenyl)sulfenyl chloride
EINECS	208-438-5

Quality Control

Our 2,4-Dinitrobenzenesulfenyl Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	96 - 100 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.