Description

Antimycin A3 is a potent, naturally occurring antibiotic and mitochondrial electron transport chain inhibitor, widely recognized for its role in biochemical research and as a reference standard. This compound is critical for studying cellular respiration, apoptosis, and oxidative stress mechanisms in various biological systems. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and agricultural sectors for its specific inhibitory activity.

Application

• Biochemical Research: As a specific inhibitor of mitochondrial complex III (bc1 complex) to study electron transport, ATP synthesis, and reactive oxygen species (ROS) generation.
• Apoptosis Studies: Used to induce and investigate the intrinsic (mitochondrial) pathway of programmed cell death in cancer research and cell biology.
• Agricultural Research: Serves as a reference compound in the study of fungicides and insecticides due to its mode of action.
• Pharmaceutical Development: Employed as a tool compound in drug discovery for metabolic diseases and oncology target validation.
• Reference Standard: Used in analytical laboratories for quality control, method development, and calibration in HPLC and LC-MS analyses.
• Bioenergetics: Applied in studies of mitochondrial function and dysfunction in models of neurodegenerative and metabolic disorders.

Basic Information

Product Name	Antimycin A3
CAS No.	522-70-3
Molecular Formula	C28H40N2O9
Molecular Weight	548.63 g/mol
Synonyms	Antimycin A; Antimycin A1; Antimycin A3; Antipiricullin; Blastmycin; Virosin; NSC 13519; 3-[(2R,3S,6S,7R,8R)-3-[(2S,3S,6S)-3-Formamido-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-6-yl]-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-8-yl]salicylamide
EINECS	208-318-6

Quality Control

Our Antimycin A3 is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure high purity and consistency, meeting the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.