Description

Demecolceine is a potent alkaloid compound derived from the autumn crocus, *Colchicum autumnale*, known for its specific biological activity as a mitotic inhibitor. This high-purity compound is critical for researchers and manufacturers requiring precise, reliable materials for advanced life science applications. It is primarily utilized in biochemical research, pharmaceutical development, and as a reference standard in analytical laboratories.

Application

• Biochemical Research: Used as a specific inhibitor of microtubule polymerization in cell biology studies to arrest cells in metaphase.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of more complex therapeutic agents.
• Reference Standard: Employed as a high-purity calibrant in analytical methods (e.g., HPLC, LC-MS) for quality control and method validation.
• Cell Cycle Studies: Essential tool for investigating mitosis, chromosome segregation, and cell division mechanisms.
• Anticancer Research: Studied for its potential effects on rapidly dividing cells in preclinical oncological research.

Basic Information

Product Name	Demecolceine
CAS No.	518-11-6
Molecular Formula	C21H25NO5
Molecular Weight	371.43 g/mol
Synonyms	Demecolcine; Colcemid; N-Deacetyl-N-methylcolchicine; Deacetylcolchicine methyl ether; NSC 3096; Omaine; Santavy's Substance F; Colecmid
EINECS	208-260-7

Quality Control

Our Demecolceine is produced and tested under a strict quality management system. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency, meeting the requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing results for assay, related substances, and identification is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.