Description

3-Beta,11-Beta,21-Trihydroxy-5-α-Pregnan-20-One is a high-purity steroid derivative, also known as 11β,21-Dihydroxy-3β-hydroxy-5α-pregnan-20-one. This compound serves as a critical pharmaceutical intermediate and reference standard in advanced research and development. It is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and life sciences sectors requiring precise, high-quality steroid building blocks for synthesis and analytical purposes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of specialized corticosteroid analogs and other therapeutic steroid molecules.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical laboratories to ensure product purity and identity.
• Biochemical Research: Employed in metabolic pathway studies, enzyme inhibition assays, and research into steroid hormone biosynthesis and regulation.
• Active Pharmaceutical Ingredient (API) Development: Serves as a starting material or intermediate in the synthesis of novel steroid-based APIs under Good Manufacturing Practice (GMP) conditions.
• Academic & Contract Research: Utilized in universities and CROs (Contract Research Organizations) for fundamental and applied research in medicinal chemistry and endocrinology.

Basic Information

Product Name	3-Beta,11-Beta,21-Trihydroxy-5-α-Pregnan-20-One
CAS No.	516-16-5
Molecular Formula	C21H34O4
Molecular Weight	350.49 g/mol
Synonyms	11β,21-Dihydroxy-3β-hydroxy-5α-pregnan-20-one; 5α-Pregnane-3β,11β,21-triol-20-one; 3β,11β,21-Trihydroxy-5α-pregnan-20-one; 11β,21-Dihydroxypregnanolone; 5α-Pregnan-3β,11β,21-triol-20-one; Tetrahydrocorticosterone; 5α-Tetrahydrocorticosterone; THB
EINECS	208-225-7

Quality Control

Our 3-Beta,11-Beta,21-Trihydroxy-5-α-Pregnan-20-One is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.