Description

4-Nitrobenzylfluoride is a versatile aromatic fluorinated building block, essential for introducing the 4-nitrobenzyl group into complex molecular architectures. Its primary value lies in its reactivity as an electrophile in nucleophilic substitution reactions, making it a key intermediate in advanced organic synthesis. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a fluorinated aromatic moiety.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides where the nitro and fluorine groups contribute to biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and lighting.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Polymer Modification: Employed to introduce functional nitrobenzyl groups into polymer chains for specialty materials.
• Dye & Pigment Intermediate: Used in the synthesis of certain azo dyes and other colored compounds.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4-Nitrobenzylfluoride
CAS No.	500-11-8
Molecular Formula	C7H6FNO2
Molecular Weight	155.13 g/mol
Synonyms	α-Fluoro-4-nitrotoluene; 1-(Fluoromethyl)-4-nitrobenzene; (4-Nitrophenyl)methyl fluoride; p-Nitrobenzyl fluoride; 4-Nitrobenzyl fluoride; 4-Nitro-α-fluorotoluene; p-Nitrobenzylfluoride
EINECS	207-896-2

Quality Control

Our 4-Nitrobenzylfluoride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	30 - 34 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.