Description

Vincristine CAS NO 57-22-7 is a potent vinca alkaloid derived from the Madagascar periwinkle plant, Catharanthus roseus. This critical active pharmaceutical ingredient (API) is essential for its potent antimitotic activity, which disrupts microtubule formation and halts cell division. It is a cornerstone chemotherapeutic agent primarily utilized in the pharmaceutical industry for the formulation of injectable oncology treatments targeting various leukemias, lymphomas, and solid tumors.

Application

• Oncological Formulations: Primary API in injectable chemotherapy drugs for treating acute lymphoblastic leukemia (ALL), Hodgkin's and non-Hodgkin's lymphoma, and other malignancies.
• Pharmaceutical Research & Development: Serves as a key reference standard and active component in preclinical and clinical studies for novel cancer therapies.
• Biochemical Research: Used as a microtubule-disrupting agent in cell biology and molecular pharmacology research to study mitosis, cell cycle arrest, and apoptosis mechanisms.
• GMP Manufacturing: Supplied as a high-purity bulk active ingredient for compliant Good Manufacturing Practice (GMP) production of finished dosage forms.
• Combination Chemotherapy Regimens: An integral component of multi-drug protocols (e.g., CHOP, VAD) for enhanced therapeutic efficacy in cancer treatment.

Basic Information

Product Name	Vincristine
CAS No.	57-22-7
Molecular Formula	C46H56N4O10
Molecular Weight	824.96 g/mol
Synonyms	Vincristine Sulfate; Leurocristine; LCR; VCR; Kyocristine; Oncovin; Vincosid; Vincristinum; 22-Oxovincaleukoblastine
EINECS	200-304-1

Quality Control

Our Vincristine is manufactured and tested under strict quality systems to meet the rigorous standards required for pharmaceutical actives. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) confirming compliance with relevant pharmacopoeial standards (e.g., USP, EP) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its strictly light-sensitive and hygroscopic nature, this material must be stored under controlled conditions. The recommended long-term storage temperature is 2°C to 8°C (refrigerated). The container should be kept in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to slightly yellow, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	NLT 98.0% and NMT 102.0% (on anhydrous basis)
Water (Karl Fischer)	NMT 5.0%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Individual impurity: NMT 1.0% Total impurities: NMT 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.