Description

4-(1,2,3-Thiadiazol-4-Yl)Benzenesulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative featuring a fused thiadiazole heterocycle, making it a high-value synthetic intermediate for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise functionalization to introduce the unique sulfonamide linkage and heterocyclic pharmacophore. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in medicinal chemistry for creating sulfonamide-based drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel sulfonamide-based drug candidates with potential biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate the thiadiazole moiety.
• Material Science Research: Serves as a precursor for creating functional polymers or organic electronic materials with specific sulfonyl properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and protein labeling.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Ligand and Catalyst Development: Utilized for preparing specialized ligands or organocatalysts containing sulfonamide and heterocyclic functionalities.

Basic Information

Product Name	4-(1,2,3-Thiadiazol-4-Yl)Benzenesulfonyl Chloride
CAS No.	499771-00-5
Molecular Formula	C8H5ClN2O2S2
Molecular Weight	260.72 g/mol
Synonyms	4-(1,2,3-Thiadiazol-4-yl)benzenesulfonyl chloride; 1,2,3-Thiadiazole-4-benzenesulfonyl chloride; 4-(1,2,3-Thiadiazol-4-yl)phenylsulfonyl chloride; p-(1,2,3-Thiadiazol-4-yl)benzenesulfonyl chloride; 4-(1,2,3-Thiadiazolyl)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-(1,2,3-thiadiazol-4-yl)-; 4-(1,2,3-Thiadiazol-4-yl)benzene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-(1,2,3-Thiadiazol-4-Yl)Benzenesulfonyl Chloride adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity suitable for research and scale-up. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.