Description

4-Bromo-3,5-Difluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs which often exhibit enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the synthesis of monomers and polymers for organic light-emitting diodes (OLEDs) and semiconductor materials, where fluorine substitution tunes electronic properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl and other structures.
• Material Science Research: Utilized in academic and industrial R&D for creating novel fluorinated polymers, coatings, and specialty chemicals with unique surface properties.

Basic Information

Product Name	4-Bromo-3,5-Difluorobenzotrifluoride
CAS No.	499238-36-7
Molecular Formula	C7H2BrF5
Molecular Weight	260.99 g/mol
Synonyms	1-Bromo-2,6-difluoro-4-(trifluoromethyl)benzene; 2,6-Difluoro-4-(trifluoromethyl)bromobenzene; 4-Bromo-3,5-difluoro-α,α,α-trifluorotoluene; 3,5-Difluoro-4-bromobenzotrifluoride; Benzene, 1-bromo-2,6-difluoro-4-(trifluoromethyl)-; α,α,α-Trifluoro-4-bromo-3,5-difluorotoluene
EINECS	Contact for details

Quality Control

Our 4-Bromo-3,5-Difluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.