Description

2-Quinolinecarbonyl Chloride, 7-Fluoro- (9Ci) is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its dual functionality, combining a reactive acid chloride group with a strategically positioned fluorine atom on the quinoline scaffold, enabling precise molecular construction. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated quinolone and quinoline-based drug candidates, potentially targeting bacterial infections, cancer, and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atom can enhance biological activity, metabolic stability, and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials, such as fluorinated polymers or small molecules for OLEDs.
• Ligand and Catalyst Development: Employed to construct sophisticated nitrogen-containing ligands for metal catalysis or as a scaffold for organocatalysts.
• Fluorescent Probe Synthesis: Utilized to create fluorophore derivatives for bioimaging and diagnostic applications, leveraging the quinoline core's inherent photophysical properties.
• Custom Synthesis and Contract Research: A critical reagent for custom synthesis houses and CROs (Contract Research Organizations) serving clients in life sciences and specialty chemicals.

Basic Information

Product Name	2-Quinolinecarbonyl Chloride, 7-Fluoro- (9Ci)
CAS No.	497959-11-2
Molecular Formula	C10H5ClFNO
Molecular Weight	209.60 g/mol
Synonyms	7-Fluoroquinoline-2-carbonyl chloride; 7-Fluoro-2-quinolinecarboxylic acid chloride; 7-Fluoro-2-quinolinecarbonyl chloride; 7-Fluoroquinoline-2-carboxylic acid chloride; 2-Carboxy-7-fluoroquinoline chloride; 7-Fluoro-2-quinolylcarbonyl chloride; 7-Fluoro-2-quinoline carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Quinolinecarbonyl Chloride, 7-Fluoro- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical data are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.