Description

Aee788 CAS NO 497839-62-0 is a potent and selective small molecule inhibitor primarily targeting receptor tyrosine kinases. This compound is a critical research tool in oncology and signal transduction studies, valued for its ability to modulate specific cellular pathways. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on cancer therapeutics and kinase biology.

Application

• Kinase Inhibition Research: Used as a reference standard and active agent in studies targeting EGFR and VEGFR family kinases.
• Oncology Drug Discovery: A key compound for in vitro and in vivo models to evaluate anti-tumor efficacy and mechanism of action.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and enzyme activity assays to identify and characterize kinase inhibitors.
• Signal Transduction Pathway Analysis: Utilized to dissect the role of specific tyrosine kinases in cellular proliferation, angiogenesis, and apoptosis.
• Pharmaceutical Intermediate: Serves as a building block or precursor in the synthesis of more complex therapeutic candidates.
• Academic & Contract Research: Supplied to universities and CROs for fundamental biological research and preclinical testing.

Basic Information

Product Name	Aee788
CAS No.	497839-62-0
Molecular Formula	C₂₉H₂₉ClFN₇O₃
Molecular Weight	578.04 g/mol
Synonyms	NVP-AEE788; AEE 788; 6-[4-[[4-(Ethylsulfonyl)piperazin-1-yl]methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; EGFR/VEGFR Inhibitor; Tyrosine Kinase Inhibitor AEE788; 4-Amino-6-(4-((4-(ethylsulfonyl)piperazin-1-yl)methyl)phenyl)-N-((R)-1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our Aee788 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.