Description

Cenicriviroc is a potent, orally bioavailable, dual antagonist of the chemokine receptors CCR2 and CCR5. This mechanism of action makes it a compound of significant interest for targeting inflammatory and fibrotic pathways. It is primarily utilized in pharmaceutical research and development for the investigation of new therapeutic agents. Cenicriviroc CAS NO 497223-28-6 is a critical intermediate and reference standard for scientists working in drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: Serves as a key active pharmaceutical ingredient (API) intermediate in the synthesis of investigational new drugs.
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in analytical laboratories.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate the efficacy and pharmacokinetics of CCR2/CCR5 inhibition.
• Mechanistic Research: A vital tool for biomedical researchers studying the role of CCR2 and CCR5 receptors in diseases such as non-alcoholic steatohepatitis (NASH), liver fibrosis, and inflammatory disorders.
• Process Chemistry: Used as a building block or intermediate in the scale-up and optimization of synthetic routes for potential therapeutics.

Basic Information

Product Name	Cenicriviroc
CAS No.	497223-28-6
Molecular Formula	C₄₀H₄₀F₂N₄O₄
Molecular Weight	662.77 g/mol
Synonyms	TAK-652; TAK 652; CVC; 8-[4-(2-Butoxyethoxy)phenyl]-1-isobutyl-N-(4-{[1-(propylsulfonyl)piperidin-4-yl]methyl}phenyl)-1,2,3,4-tetrahydro-1-benzazepine-5-carboxamide; 1,2,3,4-Tetrahydro-8-[4-[2-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[1-(propylsulfonyl)-4-piperidinyl]methyl]phenyl]-1-benzazepine-5-carboxamide; CCR2/CCR5 Dual Antagonist
EINECS	Contact for details

Quality Control

Our Cenicriviroc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.