Description

Lipid A Detoxified (Salmonella Minnesota R595) is a detoxified derivative of the lipid A component of bacterial lipopolysaccharide (LPS), specifically sourced from the Re mutant strain of Salmonella Minnesota R595. This compound is a critical research-grade biochemical tool for studying innate immune responses without the extreme endotoxic activity associated with native lipid A. It is essential for scientists and developers in the fields of immunology, vaccine adjuvant research, and pharmaceutical development, where it serves as a reference standard and a key component in mechanistic studies of Toll-like receptor 4 (TLR4) signaling pathways.

Application

• Immunological Research: Used as a reference standard and control in studies of innate immunity, TLR4/MD-2 receptor activation, and endotoxin tolerance.
• Vaccine Adjuvant Development: Serves as a model compound for developing and testing novel, less reactogenic adjuvants that modulate immune responses.
• Cell Signaling Studies: Employed to stimulate immune cells like macrophages and dendritic cells in vitro to study cytokine production and signaling cascades.
• Endotoxin Detection & Calibration: Acts as a calibrator or control in Limulus Amebocyte Lysate (LAL) assays and other endotoxin detection systems.
• Pharmaceutical Reference Standard: Utilized as a qualified reference material in quality control and assay development for biopharmaceuticals.
• Inflammation Model Systems: Applied in research models to investigate anti-inflammatory compounds and pathways with reduced septic shock risk.

Basic Information

Product Name	Lipid A Detoxified (Salmonella Minnesota R595)
CAS No.	497156-01-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Detoxified Lipid A (Salmonella minnesota R595); Monophosphoryl Lipid A (MPLA) analog; Salmonella minnesota Re 595 lipid A, detoxified; TLR4 agonist (detoxified); Bacterial Lipopolysaccharide derivative; Endotoxin derivative; LA-Detox; LPS-derived adjuvant
EINECS	Contact for details

Quality Control

Our Lipid A Detoxified is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for critical research applications. Each lot is characterized using advanced analytical techniques to confirm identity and the absence of significant endotoxic activity. Certificates of Analysis (COA) detailing purity, biological activity (e.g., TLR4 activation assays, LAL test), and other relevant specifications are provided to guarantee it meets the exacting standards required for immunological and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Endotoxin Activity (LAL)	Significantly reduced vs. native Lipid A
Water Content (KF)	≤ 5.0 %
Biological Activity (Cell-based assay)	Confirms TLR4 agonist activity (detoxified profile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.