Description

Gli1-Mediated Transcription Inhibitor CAS NO 496794-70-8 is a potent and selective small molecule inhibitor of the Gli1 transcription factor, a key effector in the Hedgehog (Hh) signaling pathway. This compound is a critical research tool for studying aberrant Hh pathway activation, which is implicated in various cancers and developmental disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, regenerative medicine, and molecular biology.

Application

• Oncology Research: Investigation of Hedgehog pathway-driven cancers such as basal cell carcinoma, medulloblastoma, and pancreatic cancer.
• Drug Discovery & Development: Serving as a lead compound or pharmacological tool for screening and validating novel Hh pathway inhibitors.
• Stem Cell & Developmental Biology Studies: Probing the role of Gli1 in tissue regeneration, stem cell maintenance, and embryonic development.
• Mechanistic Studies: Elucidating downstream gene targets and signaling crosstalk of the Gli1 transcription factor in cellular models.
• High-Content Screening (HCS): Utilization in automated assay systems to identify modulators of the Hedgehog signaling pathway.

Basic Information

Product Name	Gli1-Mediated Transcription Inhibitor
CAS No.	496794-70-8
Molecular Formula	C₂₁H₁₉N₃O₃S
Molecular Weight	393.46 g/mol
Synonyms	Gli1 Inhibitor; GANT61; Gli1/2 Inhibitor XI; GANT-61; N-((4-(2,5-Dimethyl-1H-pyrrol-1-yl)phenyl)sulfonyl)-3,5-dimethylbenzamide; Hedgehog Pathway Inhibitor GANT61; Gli Antagonist 61
EINECS	Contact for details

Quality Control

Our Gli1-Mediated Transcription Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.